Stage 12 - September 7: Aranda de Duero - Guadalajara, 169.3 km

Stage 12 features only one major obstacle, the third-category Alto de Santibáñez de Ayllón after 66 kilometres. The climb may serve as a springboard for a large break who are prepared to cooperate for the final 100 kilometres. The last three kilometres are uphill, so the sprinters teams may be prepared write the stage off, giving a break more of a chance.

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