The Dutchman, who spent eight months on the sidelines recovering from a career and life-threatening crash at last year's Tour de Pologne, returned to action this April and to winning ways at the recent Tour de Wallonie.
He will return to the scene of his Grand Tour debut in 2019, when he won two stages of that year's Vuelta, in his second season as a professional.
Although the Vuelta once again features a plethora of summit finishes, there are more opportunities than usual for the fast finishers, with six potential bunch finishes for a field that also includes Caleb Ewan (Lotto Soudal) and Arnaud Démare (Groupama-FDJ).
Jakobsen will be assisted by a lead-out train that includes Florian Sénéchal, Josef Cerny, and Bert Van Lerberghe, while Zdenek Stybar also has the engine to assist in the run-ins of the flatter stages.
The rest of Deceuninck-QuickStep's eight-man squad is geared towards the hillier terrain, with James Knox providing a possible GC option alongside the younger duo of Andrea Bagioli and Mauri Vansevenant.
Knox finished 11th at the 2019 Giro before riding as a mountain domestique at the last two editions of the Giro d'Italia for Joao Almeida.
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Bagioli, 22, made his Grand Tour debut at last year's late-season Vuelta in his encouraging first season as a professional, while Vansevenant, another 22-year-old second-year pro, makes his three-week debut after lighting up the last two Ardennes Classics campaigns.
“La Vuelta is La Vuelta, one of the hardest races of the season, but we are confident, as we have a strong team capable of fighting for a good result on almost all stages," said team director Wilfried Peeters.
"Fabio is back in a Grand Tour after two years and comes at the start following a very good Tour de Wallonie and supported by a solid sprint train, consisting of Josef, Florian and Bert, all riders who have shown their quality in the past.
"Zdenek and Josef are both capable of seizing the opportunity if it will present itself, while James, Mauri and Andrea can try and do something in the mountains stages, where they have what it takes to go for a nice result."
The 2021 Vuelta a España gets underway in Burgos on Saturday, August 14, and concludes with a time trial into Santiago de Compostela on Sunday, September 5.
Patrick is an NCTJ-accredited journalist with a bachelor’s degree in modern languages (French and Spanish) and a decade’s experience in digital sports media, largely within the world of cycling. He re-joined Cyclingnews as Deputy Editor in February 2026, having previously spent eight years on staff between 2015 and 2023. In between, he was Deputy Editor at GCN and spent 18 months working across the sports portfolio at Future before returning to the cycling press pack. Patrick works across Cyclingnews’ wide-ranging output, assisting the Editor in global content strategy, with a particular focus on shaping CN's news operation.
