Schleck has not raced since fracturing his hip during the time trial stage of the Criterium du Dauphine on June 7.
He was forced to miss the Tour de France and also missed planned comebacks at the US ProCycling Challenge and the more recent GP Fourmies in France. He has blamed pain in his hip and leg as the cause of his long absence from competition.
"I'm very disappointed that I couldn't show anything so far this year. This has been a dreadful season for me and I desperately want to put it behind me. I still hope to return to racing before the season ends," Schleck said in early September when he decided not to ride the GP Fourmies.
Binche-Tournai-Binche – held in the south-western French-speaking part of Belgium, traditionally brings down the curtain on the Belgian cycling season. Binche will host the start of Fleche-Wallonne in 2013 and host the 2108 Belgian national road race championships.
RadioShack-Nissan has also named Matthew Busche, Laurent Didier, Ben Hermans, Gregory Rast, Jesse Sergent and Robert Wagner in the line-up for Binche-Tournai-Binche, with Dirk Demol as directeur sportif.