The Briton attacked with more than 5km to go to win the stage by just over a minute from Tadej Pogačar (UAE Team Emirates) and 1:30 on third-placed Alexey Lutsenko (Astana).
Now with 1:07 over Pogačar in the general classification, Yates has a sprint stage to enjoy the leader's jersey before the race returns to the same finish on stage 5.
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