Pozzovivo also injured his right elbow in the crash, which happened just after the start of the 176km stage 3 from Pergine Valsugana to Condino and required stitches.
The 30-year-old was sitting 13th overall in the Giro del Trentino after stage 2, having finished the previous stage's major uphill finish just nine seconds off the pace of Bradley Wiggins and Vincenzo Nibali.
According to the AG2R La Mondiale team, the injuries will not affect Pozzovivo's participation in the upcoming Giro d'Italia.
The team has not yet decided who will replace him in Sunday's La Doyenne.
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