The Rabobank rider had a pin installed in his leg on Sunday night at the Meander Medical Center in Amersfoort in the Netherlands. He will remain in hospital a few days, and must have ten days of absolute rest, before starting rehabilitation.
Rabobank sport director Erik Breukink said that Gesink did not remember how the crash happened.
The crash is another blow for the 26-year old after a difficult 12 months. His father died in October 2010 as the result of a cycling accident. Gesink started well in the season, winning two stages in the Tour of Oman en route to overall victory. A crash at the Tour de France left him with back and hip injuries and he finished the race 33rd overall. He recently he finished second in the GP de Quebec, and was looking forward to repeating his two-time win in the Giro dell'Emilia. Now his season is over and he faces a winter of rehabilitation and physiotherapy.
Gesink's place on the Worlds road team will be taken by Rabobank teammate Steve Kruijswijk.
In another team change, Dominique Rollin (FDJ) has withdrawn from the Canadian team. He has not recovered from injuries suffered in a crash at the GP de Montreal. His place on the road race will be taken by Michael Barry of Team Sky.