Kwiatkowski has not raced since beating Peter Sagan and Julian Alaphilippe in a close sprint in the Via Roma, while the hilly Basque stage race will also see a return to racing for Henao after he held off a last-stage attack from Alberto Contador to win Paris-Nice.
Kwiatkowski and Henao will join forces to take on Contador, who leads the Trek-Segafredo team. Alejandro Valverde (Movistar) is arguably the favourite for the six-day race after dominating the Volta a Catalunya. Other contenders include Romain Bardet (AG2R-La Mondiale), Nicolas Roche (BMC), Rigoberto Uran (Cannondale-Drapac), Tim Wellens (Lotto Soudal), Adam Yates (Orica-Scott) and Warren Barguil (Team Sunweb).
Team Sky have selected a team of experience and youth, with Tao Geoghegan Hart included in the squad on the day he celebrates his 22nd birthday.
Also in the eight-rider roster are Michal Golas, Sebastian Henao, Vasil Kiryienka, David Lopez and Mikel Nieve. The same riders will compete in the GP Indurain on Saturday April 1 and then head to Pamplona for the start of the Tour of the Basque Country on Tuesday.
Only the first stage suits the sprinters, with stage 5 to Eibar ending with a nasty climb to the finish line. The final 27.7km individual time trial will crown the overall winner
Team Sky for the Tour of the Basque Country: Tao Geoghegan Hart, Michal Golas, Sebastian Henao, Sergio Henao, Vasil Kiryienka, Michal Kwiatkowski, David Lopez and Mikel Nieve.